1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole

Base Information

• Chemical Name: 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole
• CAS No.: 128993-43-1
• Molecular Formula: C₂₀H₃₄N₂OSi
• Molecular Weight: 346.588
• Mol file: 128993-43-1.mol

Synonyms:1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole

Chemical Property of 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole

There total 4 articles about 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-benzyl-4,5-dihydroimidazole (61764-86-1) + tert-butyldimethylsilyl chloride (18162-48-6) + butyraldehyde (123-72-8) → 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole (128993-43-1)

Guidance literature:

1-benzyl-4,5-dihydroimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

butyraldehyde; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; hexane; for 16h; Inert atmosphere;

DOI:10.1039/c3ob40884a

Reference yield: 50.0%

1-benzyl-2-(1-hydroxybutyl)-4,5-dihydroimidazole (128993-22-6) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole (128993-43-1)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1016/S0040-4039(00)88877-2

Reference yield:

1-benzyl-4,5-dihydroimidazole (61764-86-1) → 1-benzyl-2-(1-tert-butyldimethylsilyloxybutyl)-4,5-dihydroimidazole (128993-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, -78 deg C

2: 50 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

With dmap; n-butyllithium; In dichloromethane;

DOI:10.1016/S0040-4039(00)88877-2

upstream raw materials:

1-benzyl-2-(1-hydroxybutyl)-4,5-dihydroimidazole

tert-butyldimethylsilyl chloride

1-benzyl-4,5-dihydroimidazole

butyraldehyde