7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1335116-92-1
Molecular Formula:C₃₁H₃₆F₃N₃O₆S
Molecular Weight:635.705
Hs Code.:

Synonyms:7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Technology Process of 7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 10 articles about 7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1335116-91-0
methyl 7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1335116-92-1
7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: methyl 7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate; With water; potassium hydroxide; In methanol; Reflux;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1335116-92-1
7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: hydrogen bromide; acetic acid / 120 h / Reflux

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

3.2: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: dimethyl sulfoxide / 20 °C

5.2: 2 h

6.1: Oxone / water; tetrahydrofuran / 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

8.1: acetonitrile / 3 h

9.1: potassium hydroxide; water / methanol / Reflux

9.2: pH 6

With Oxone; N-Bromosuccinimide; oxalyl dichloride; water; hydrogen bromide; caesium carbonate; acetic acid; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 64465-53-8
4-fluoro-3-methoxyaniline

: 1335116-92-1
7-(ethyloxy)-6-(ethylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: hydrogen bromide; acetic acid / 120 h / Reflux

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

3.2: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: dimethyl sulfoxide / 20 °C

5.2: 2 h

6.1: Oxone / water; tetrahydrofuran / 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

8.1: acetonitrile / 3 h

9.1: potassium hydroxide; water / methanol / Reflux

9.2: pH 6

With Oxone; N-Bromosuccinimide; oxalyl dichloride; water; hydrogen bromide; caesium carbonate; acetic acid; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;