(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Base Information

Chemical Name:(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate
CAS No.:1380299-26-2
Molecular Formula:C₂₆H₂₁NO₆S
Molecular Weight:475.522
Hs Code.:

Synonyms:(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Chemical Property of (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

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Technology Process of (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

There total 4 articles about (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1380299-25-1
C₁₈H₁₆O₈

: 341027-48-3
(4R)-2-benzyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester

: 1380299-26-2
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In 1,2-dichloro-ethane; at 120 ℃; for 0.0388889h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/chem.201103936

Reference yield:

: 62935-72-2
2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid

: 1380299-26-2
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.04 h / 120 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103936

Reference yield:

: 140-29-4
phenylacetonitrile

: 1380299-26-2
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 0 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 1,2-dichloro-ethane / Inert atmosphere

3.2: 0.03 h / 140 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2012.01.048