(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Base Information

Chemical Name:(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid
CAS No.:1374967-36-8
Molecular Formula:C₂₅H₁₉NO₆S
Molecular Weight:461.495
Hs Code.:

Synonyms:(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Chemical Property of (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Technology Process of (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

There total 4 articles about (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1380299-26-2
(3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate

: 1374967-36-8
(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; water; Inert atmosphere;
DOI:10.1002/chem.201103936

Reference yield:

: 62935-72-2
2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid

: 1374967-36-8
(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0.04 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103936

Reference yield:

: 5442-34-2
ethyl 2-phenylacetimidate hydrochloride

: 1374967-36-8
(3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / Inert atmosphere

2.2: 0.03 h / 140 °C / Microwave irradiation; Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2012.01.048