N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

Base Information

Chemical Name:N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide
CAS No.:1427406-87-8
Molecular Formula:C₂₀H₁₃F₄NO₂
Molecular Weight:375.322
Hs Code.:

Synonyms:N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

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Chemical Property of N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

Chemical Property:

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Technology Process of N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

There total 4 articles about N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427330-97-9
3-amino-2 ,4-difluoro-phenol

: C₁₄H₉ClF₂O

: 1427406-87-8
N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 72518-16-2
3-bromo-2-fluoro-5-methyl-benzoic acid

: 1427406-87-8
N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

3: sodium hydrogencarbonate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 452-62-0
3-bromo-4-fluorotoluene

: 1427406-87-8
N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

4.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetonitrile;