72518-16-2

Upstream product

• 124-38-9 carbon dioxide 
• 444-13-3 1,3-dibromo-2-fluoro-5-methylbenzene 
• 452-62-0 3-bromo-4-fluorotoluene 

Downstream Products

• 307975-05-9 (3-bromo-2-fluoro-5-methyl-phenyl)-methanol 
• 447463-77-6 1-bromo-3-bromomethyl-2-fluoro-5-methyl-benzene 
• 447463-27-6 (3-{4-[1-(3-bromo-2-fluoro-5-methyl-benzyloxy)-ethyl]-2-methoxy-5-nitro-phenoxy}-propyl)-carbamic acid tert-butyl ester 
• 1427330-93-5 2-[2,4-difluoro-3-[[2-fluoro-3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid 
• 1427406-89-0 C₂₄H₂₁F₄NO₃ 
• 1427406-88-9 2,4-difluoro-3-[[2-fluoro-3-(3-fluorophenyl)-5-methylphenyl]methylamino]phenol 
• 1427406-87-8 N-(2,6-difluoro-3-hydroxyphenyl)-2-fluoro-3-(3-fluorophenyl)-5-methyl-benzamide 
• 1427406-52-7 C₂₄H₂₃F₂NO₃ 
• 1427408-13-6 isopropyl 2-[3-[[2-fluoro-3-(3-fluorophenyl)-5-methylphenyl]methylamino]-2,4-dimethylphenoxy]acetate 
• 1427408-11-4 2-fluoro-3-(3-fluorophenyl)-N-(3-hydroxy-2,6-dimethyl-phenyl)-5-methylbenzamide 
• 1427406-48-1 C₂₃H₂₀F₃NO₃ 
• 1427408-01-2 C₂₆H₂₆F₃NO₃ 
• 1427408-00-1 4-fluoro-3[[2-fluoro-3-(fluorophenyl)-5-methylphenyl]methylamino]-2-methylphenol 
• 1427407-99-5 N-(6-fluoro-3-hydroxy-2-methylphenyl)-3-(3-fluorophenyl)-5-methoxybenzamide 

Relevant academic research and scientific papers

FACTOR IXA INHIBITORS

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

FACTOR IXA INHIBITORS

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Compounds and Compositions as Protein Kinase Inhibitors

The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is