[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

Base Information

Chemical Name:[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate
CAS No.:1606976-53-7
Molecular Formula:C₂₀H₁₉BrClN₃O₂S
Molecular Weight:480.813
Hs Code.:

Synonyms:[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

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Chemical Property of [2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

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Technology Process of [2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

There total 6 articles about [2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1606976-52-6
[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methanol

: 75-36-5
acetyl chloride

: 1606976-53-7
[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 2h;

Reference yield:

: 202336-16-1
5-chlorothiophene-2-carboxamidine hydrochloride

: 1606976-53-7
[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / ethanol; methanol / 7 h / Reflux

2: trichlorophosphate / 4 h / 90 °C

3: hydrogenchloride; acetic acid / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

4: diborane / tetrahydrofuran / 20 °C

5: pyridine; dmap / 2 h / 20 °C

With pyridine; hydrogenchloride; dmap; sodium methylate; acetic acid; diborane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;

Reference yield:

: 1174196-85-0
4-chloro-2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidine

: 1606976-53-7
[2-bromo-5-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; acetic acid / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

2: diborane / tetrahydrofuran / 20 °C

3: pyridine; dmap / 2 h / 20 °C

With pyridine; hydrogenchloride; dmap; acetic acid; diborane; In tetrahydrofuran; 1,4-dioxane;