1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Base Information

• Chemical Name: 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
• CAS No.: 1425937-06-9
• Molecular Formula: C₂₅H₂₃FN₄O₃
• Molecular Weight: 445.47

Synonyms:1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Chemical Property of 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Chemical Property:

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Technology Process of 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 1 articles about 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-23-0) + [11C]methyl triflate (145577-00-0) → 1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[11C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-06-9)

Guidance literature:

With sodium hydroxide; In acetone; at 10 - 35 ℃; for 0.0111111 - 0.0166667h;

Reference yield:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[11C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-06-9) + [d2-18F]-fluorobromomethane (844446-46-4) → 5-([18F]fluoromethoxy-d2)-1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-07-0)

Guidance literature:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one; With water; sodium hydroxide;

[d₂-¹⁸F]-fluorobromomethane; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667 - 0.25h;

Reference yield:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[11C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-06-9) + 1-bromo-2-[18F]fluoroethane-d4 (861395-74-6) → 5-(2-[18F]fluoroethoxy-d4)-1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (1425937-08-1)

Guidance literature:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-[¹¹C]methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one; With water; sodium hydroxide;

1-bromo-2-[¹⁸F]fluoroethane-d₄; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667 - 0.25h;

upstream raw materials:

1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

[11C]methyl triflate

Downstream raw materials:

5-([18F]fluoromethoxy-d2)-1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

5-(2-[18F]fluoroethoxy-d4)-1-[2-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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