ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

Base Information

Chemical Name:ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride
CAS No.:95250-10-5
Molecular Formula:C₂₀H₂₂Cl₂N₂O₄*2ClH
Molecular Weight:498.234
Hs Code.:

Synonyms:ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

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Chemical Property of ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

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Technology Process of ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

There total 6 articles about ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.07%

: 95250-10-5
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

Guidance literature:

Reference yield: 89.0%

: 95250-08-1
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(chloroacetamido)methyl>-4-hydroxybenzyl>-2-benzofurancarboxylate

: 95250-10-5
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 4h; Heating;
DOI:10.1021/jm50001a009

Reference yield:

: 90246-55-2
6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid

: 95250-10-5
ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis(aminomethyl)-4-hydroxybenzyl>-2-benzofurancarboxylate dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / conc. H₂SO₄ / 24 h / Ambient temperature

2: 66 percent / trifluoroacetic acid, NaBH₄ / CH₂Cl₂ / Ambient temperature

3: 1.) conc. H₂SO₄, 2.) conc. H₂SO₄ / 1.) acetic acid, RT, overnight, 2.) RT, overnight

4: 89 percent / conc. aq. HCl / ethanol / 4 h / Heating

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm50001a009