ETHYL 4-(2-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-(2-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
• CAS No.: 99931-83-6
• Molecular Formula: C₁₁H₁₆N₄O₂
• Molecular Weight: 236.274
• Mol file: 99931-83-6.mol

Synonyms:ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate

Chemical Property of ETHYL 4-(2-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

Chemical Property:

Purity/Quality:

Ethyl4-(2-pyrimidinyl)-1-piperazinecarboxylate 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-(2-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

There total 2 articles about ETHYL 4-(2-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + 4-ethoxycarbonylpiperazine (120-43-4) → ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate (99931-83-6)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; Heating;

Reference yield:

2-chloropyrimidine (1722-12-9,1195939-87-7) + 1-ethoxycarbonylpiperazine hydrochloride (24280-45-3) → ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate (99931-83-6)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1021/jo50017a004

Reference yield: 82.0%

ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate (99931-83-6) → N-(2-pyridinyl)piperazine (20980-22-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

upstream raw materials:

2-chloropyrimidine

1-ethoxycarbonylpiperazine hydrochloride

4-ethoxycarbonylpiperazine

Downstream raw materials:

N-(2-pyridinyl)piperazine

5-chloro-2-(1-piperazinyl)-pyrimidine

4-[4-(5-Chloro-pyrimidin-2-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one

Refernces

• 1、 Valenta, Vladimir,Holubek, Jiri,Svatek, Emil,Protiva, Miroslav. "POTENTIAL CHOLINERGIC AND ANTICHOLINERGIC COMPOUNDS: SYNTHESIS OF 2,8-SUBSTITUTED 2,8-DIAZASPIRODECANE-1,3-DIONES". . p. 2304 - 2316. Retrieved 2007/10/02.