24280-45-3

Basic information

• Product Name: ethyl piperazine-1-carboxylate monohydrochloride
• Synonyms: ethyl piperazine-1-carboxylate monohydrochloride;NSC26174;Ethyl 1-piperazinecarboxylate Hydrochloride
• CAS NO: 24280-45-3
• Molecular Formula: C₇H₁₄N₂O₂*ClH
• Molecular Weight: 194.6592
• EINECS: 246-118-8
• Mol File: 24280-45-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 237°Cat760mmHg
• Flash Point: 97.1°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.0459mmHg at 25°C
• CAS DataBase Reference: ethyl piperazine-1-carboxylate monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl piperazine-1-carboxylate monohydrochloride(24280-45-3)
• EPA Substance Registry System: ethyl piperazine-1-carboxylate monohydrochloride(24280-45-3)

Safety Data

• Hazardous Substances Data: 24280-45-3(Hazardous Substances Data)

Usage

General Description

Ethyl piperazine-1-carboxylate monohydrochloride is a chemical compound that belongs to the piperazine family. It is a salt molecule formed when ethyl piperazine-1-carboxylate, an organic compound, reacts with hydrochloric acid. This chemical is commonly used in the pharmaceutical industry as a precursor in the synthesis of various drugs, including antihistamines and antipsychotic medications. It is also used as a building block in the synthesis of organic compounds and as a reagent in chemical research. The monohydrochloride salt form of ethyl piperazine-1-carboxylate helps to improve the solubility and stability of the compound, making it more suitable for use in drug development and research applications.

InChI:InChI=1/C7H14N2O2.ClH/c1-2-11-7(10)9-5-3-8-4-6-9;/h8H,2-6H2,1H3;1H

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 116-54-1 dichloroacetic acid methyl ester 
• 219509-82-7 tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate 

Downstream Products

• 13919-78-3 1-(4-chlorophenyl)-3-[(N₄-ethoxycarbonyl)piperazyl]-1-oxo-propane hydrochloride 
• 55829-12-4 4-[cyano-(2,3,4-trimethoxy-phenyl)-methyl]-piperazine-1-carboxylic acid ethyl ester 
• 63981-46-4 4,4'-methanediyl-bis-piperazine-1-carboxylic acid diethyl ester 
• 99931-83-6 ethyl 4-(2-pirymidinyl)-1-piperazinecarboxylate 

Relevant articles and documents

Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines

The present invention discloses aromatic heterocyclic derivatives and applications of the aromatic heterocyclic derivatives in medicines, and specifically provides a class of aromatic heterocyclic compounds or stereoisomers, geometric isomers, tautomers, racemic bodies, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the compounds. The present invention further discloses uses of the compounds or pharmaceutical compositions in drug preparation, wherein the drug is used for treatment of respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).