N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

Base Information

Chemical Name:N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide
CAS No.:1480644-42-5
Molecular Formula:C₂₃H₁₉ClN₂O₅
Molecular Weight:438.867
Hs Code.:

Synonyms:N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

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Chemical Property of N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

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Technology Process of N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

There total 3 articles about N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.2%

: 1480644-35-6
N-(1-(3-chlorophenyl)-3-(3-acetoxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

: 1480644-42-5
N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; at 16 - 20 ℃; for 5h; chemoselective reaction;
DOI:10.1080/00397911.2013.796381

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 1480644-42-5
N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / chloroform / 35 °C / Cooling with ice

2: acetyl chloride; trifluoroacetic acid

3: lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 16 - 20 °C

With lithium hydroxide monohydrate; sodium carbonate; acetyl chloride; trifluoroacetic acid; In tetrahydrofuran; chloroform; 2: |Dakin-West Ketone Synthesis;
DOI:10.1080/00397911.2013.796381

Reference yield:

: 555-21-5,34512-13-5,174848-08-9
4-Nitrophenylacetonitrile

: 587-04-2
m-Chlorobenzaldehyde

: 1480644-42-5
N-(1-(3-chlorophenyl)-3-(3-hydroxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / chloroform / 0.5 h / Cooling with ice

1.2: 25 h / 45 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 16 - 20 °C

With lithium hydroxide monohydrate; trifluoroacetic acid; In tetrahydrofuran; chloroform; 1.1: |Dakin-West Ketone Synthesis / 1.2: |Dakin-West Ketone Synthesis;
DOI:10.1080/00397911.2013.796381