[(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester

Base Information

• Chemical Name: [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester
• CAS No.: 97939-10-1
• Molecular Formula: C₉H₁₄NO₄P
• Molecular Weight: 231.188
• Mol file: 97939-10-1.mol

Synonyms:[(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester

Chemical Property of [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester

There total 2 articles about [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl (S)-hydroxy-(2-nitrophenyl)methylphosphonate (89429-98-1) → [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester (97939-10-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 2280 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(00)61920-2

Reference yield:

2-nitro-benzaldehyde (552-89-6) → [(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester (97939-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: quinine / toluene

2: H₂ / 5percent Pd/C / methanol / 3 h / 2280 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; Quinine; In methanol; toluene;

DOI:10.1016/S0040-4039(00)61920-2

Reference yield:

[(S)-(2-Amino-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester (97939-10-1) → s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate (97939-09-8)

Guidance literature:

With hydrogenchloride; copper(l) chloride; sodium nitrite; Yield given. Multistep reaction; 1.)H₂O, 0 deg C_. 2.) 3 h;

DOI:10.1016/S0040-4039(00)61920-2

upstream raw materials:

dimethyl (S)-hydroxy-(2-nitrophenyl)methylphosphonate

2-nitro-benzaldehyde

Downstream raw materials:

s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate

dimethyl (S)-phenyl(hydroxy)methylphosphonate