s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate

Base Information

• Chemical Name: s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate
• CAS No.: 97939-09-8
• Molecular Formula: C₉H₁₂ClO₄P
• Molecular Weight: 250.619
• Mol file: 97939-09-8.mol

Synonyms:s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate

Chemical Property of s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate

There total 12 articles about s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl phosphite (96-36-6,868-85-9) + 2-chloro-benzaldehyde (89-98-5) → (+/-)-dimethyl hydroxy(2-chlorophenyl)methylphosphonate (97939-09-8,6329-47-1)

Guidance literature:

With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/cjoc.201300615

Reference yield: 94.0%

2-chloro-benzaldehyde (89-98-5) + Dimethyl phosphite (868-85-9) → s(-)-dimethyl o-chloro-α-hydroxybenzylphosphonate (97939-09-8)

Guidance literature:

2-chloro-benzaldehyde; Dimethyl phosphite; With C₄₁H₆₄AlClN₂O₂; potassium carbonate; In diethyl ether; at -30 ℃; for 24h;

With hydrogenchloride; water; In diethyl ether; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.200905158

Reference yield: 93.0%

2-chloro-benzaldehyde (89-98-5) + Dimethyl phosphite (868-85-9) → (+/-)-dimethyl hydroxy(2-chlorophenyl)methylphosphonate (97939-09-8,6329-47-1)

Guidance literature:

With triethylamine; In acetone; for 0.166667h; Reflux;

DOI:10.1039/c9nj02144b

upstream raw materials:

2-chloro-benzaldehyde

Dimethyl phosphite

dimethyl trimethylsilyl phosphite

methyl phosphite

Downstream raw materials:

(2,4-dichloro-phenoxy)-acetic acid (2-chloro-phenyl)-(dimethoxy-phosphoryl)-methyl ester

chloro-acetic acid (2-chloro-phenyl)-(dimethoxy-phosphoryl)-methyl ester

C₂₁H₂₈Cl₃O₆PSi₂

O,O-dimethyl 1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-ylcarbonyloxy-(2-chlorophenyl)methyl-phosphonate