1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Name:1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:296775-20-7
Molecular Formula:C₆₀H₉₅N₁₁O₁₀
Molecular Weight:1130.48
Hs Code.:

1-[2-(5-{[1-(2-amino-3-<i>tert</i>-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-<i>tert</i>-butoxy-butyryl]-pyrrolidine-2-carboxylic acid <i>tert</i>-butyl ester

Synonyms:1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of 1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 20 articles about 1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 263847-08-1
(2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-azidopyrrolidine-2-carboxylic acid

: 296775-20-7
1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CMC; HOBT / CH₂Cl₂ / 25 °C

2: Et₂NH / acetonitrile / 2 h / 25 °C

3: EDAC; HOBT; NMM / 1-methyl-pyrrolidin-2-one / 25 °C

4: Et₂NH / acetonitrile / 2 h / 25 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile; 1: Acylation / 2: Substitution / 3: Acylation / 4: Substitution;
DOI:10.1016/S0968-0896(00)00097-3

Reference yield:

: 296774-68-0
C₇₅H₁₀₅N₁₁O₁₂

: 296775-20-7
1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With diethylamine; In acetonitrile; at 25 ℃; for 2h;
DOI:10.1016/S0968-0896(00)00097-3

Reference yield:

: 3304-51-6,118578-06-6
N-carboxybenzyl-L-ornithine

: 296775-20-7
1-[2-(5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-{4-[4-(4-octyloxy-phenyl)-piperazin-1-yl]-benzoylamino}-pentanoylamino)-3-tert-butoxy-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: aq. Na₂CO₃ / dioxane / 0 - 25 °C

2: 11 g / EDAC; HOBT / 25 °C

3: Et₂NH / dimethylformamide / 4 h / 25 °C

4: 1.39 g / DIPEA / dimethylformamide / 48 h / 50 °C

5: H₂ / Pd(OH)2 / ethanol; acetic acid / 5 h / 25 °C

6: CMC; HOBT / CH₂Cl₂ / 25 °C

7: Et₂NH / acetonitrile / 2 h / 25 °C

8: EDAC; HOBT; NMM / 1-methyl-pyrrolidin-2-one / 25 °C

9: Et₂NH / acetonitrile / 2 h / 25 °C

With 4-methyl-morpholine; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1: Acylation / 2: Acylation / 3: Substitution / 4: Acylation / 5: Hydrogenolysis / 6: Acylation / 7: Substitution / 8: Acylation / 9: Substitution;
DOI:10.1016/S0968-0896(00)00097-3