2-phenyl-1H-indol-6-ylmethyl acetate

Base Information

• Chemical Name: 2-phenyl-1H-indol-6-ylmethyl acetate
• CAS No.: 1262881-06-0
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• Mol file: 1262881-06-0.mol

Synonyms:2-phenyl-1H-indol-6-ylmethyl acetate

Chemical Property of 2-phenyl-1H-indol-6-ylmethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-phenyl-1H-indol-6-ylmethyl acetate

There total 2 articles about 2-phenyl-1H-indol-6-ylmethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-phenyl-1H-indole-6-yl)methanol (1262881-04-8) + acetic anhydride (108-24-7) → 2-phenyl-1H-indol-6-ylmethyl acetate (1262881-06-0)

Guidance literature:

(2-phenyl-1H-indole-6-yl)methanol; acetic anhydride; With pyridine; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

2-phenyl-indole-6-carboxylic acid (110073-83-1) → 2-phenyl-1H-indol-6-ylmethyl acetate (1262881-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 9.08 h / 20 - 50 °C / Cooling with ice

1.2: 20 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

Reference yield:

2-phenyl-1H-indol-6-ylmethyl acetate (1262881-06-0) + ethyl 6-formyl-2-pyridinecarboxylate (21908-10-1) → ethyl 6-(6-acetoxymethyl-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate (1262881-08-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; Cooling with ice;

upstream raw materials:

2-phenyl-indole-6-carboxylic acid

(2-phenyl-1H-indole-6-yl)methanol

acetic anhydride

Downstream raw materials:

ethyl 6-(6-acetoxymethyl-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate

6-(6-Hydroxymethyl-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylic acid

Refernces