(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole
CAS No.:1301708-08-6
Molecular Formula:C₃₆H₄₁N₂P
Molecular Weight:532.709
Hs Code.:

Synonyms:(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

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Chemical Property of (4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

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Technology Process of (4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

There total 5 articles about (4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1301708-02-0
(4R,5R)-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

: 100-39-0
benzyl bromide

: 1301708-08-6
(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: (4R,5R)-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole; With potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield:

: 445-28-3
2-fluorobenzamide

: 1301708-08-6
(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 19.3 h / 20 °C / Inert atmosphere

2.1: triethylamine / ethanol / 92 h / 20 °C / Inert atmosphere; Reflux

3.1: tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.1: potassium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 21 h / 20 °C / Inert atmosphere

With potassium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201003314

Reference yield:

: 1301707-87-8
(4R,5R)-4,5-di-tert-butyl-2-(2'-fluorophenyl)-4,5-dihydro-1H-imidazole

: 1301708-08-6
(4R,5R)-1-benzyl-4,5-di-tert-butyl-2-(2'-(diphenylphosphanyl)phenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 21 h / 20 °C / Inert atmosphere

With potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.201003314