(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

Base Information

Chemical Name:(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene
CAS No.:1339125-60-8
Molecular Formula:C₂₃H₂₃ClN₄
Molecular Weight:390.915
Hs Code.:

Synonyms:(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

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Chemical Property of (RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

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Technology Process of (RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

There total 9 articles about (RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (RS)-8-chloro-1-(4-phenylcyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene hydrochloride

: 1339125-60-8
(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

Guidance literature:: formaldehyd; (RS)-8-chloro-1-(4-phenylcyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene hydrochloride; With triethylamine; In methanol; Reflux;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃;

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1339125-58-4
(RS)-8-chloro-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene hydrochloride

: 1339125-60-8
(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

Guidance literature:: formaldehyd; (RS)-8-chloro-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene hydrochloride; With triethylamine; In methanol; Reflux;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃;

With water; sodium hydroxide; In methanol;

Reference yield:

: 1226807-97-1
7-chloro-2-thioxo-1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester

: 1339125-60-8
(RS)-8-chloro-5-methyl-1-(4-phenyl-cyclohex-3-enyl)-5,6-dihydro-4H-2,3,5,10b-tetraazabenzo[e]azulene

Guidance literature:: Multi-step reaction with 4 steps

1.1: butan-1-ol / 20 h / Reflux

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.5 h / -65 - -50 °C

2.2: 1.08 h

3.1: tetrahydrofuran / 2 h / 20 °C

4.1: hydrogenchloride / 50 °C

4.2: Reflux

4.3: 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478