Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Base Information

Chemical Name:Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester
CAS No.:129365-66-8
Molecular Formula:C₅₉H₆₄FO₁₅P₃
Molecular Weight:1125.07
Hs Code.:

Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Synonyms:Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Suppliers and Price of Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

There total 9 articles about Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 129365-65-7
(1S,2S,3R,4S,5S,6R)-3-Benzyloxy-5-(1-ethoxy-ethoxy)-6-fluoro-cyclohexane-1,2,4-triol

: 129365-66-8
Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 8h;
DOI:10.1021/ja00176a055

Reference yield:

: 129444-05-9
(3aS,4S,4aR,7aS,8S,8aS)-8-Fluoro-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol

: 129365-66-8
Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / NaH / tetrahydrofuran / 12 h / 0 - 23 °C

2: 86 percent / methanol. HCl / CH₂Cl₂ / 0.67 h / 23 °C

3: 92 percent / pyridine, 4-dimethylaminopyridine (DMAP) / 12 h / 23 °C

4: 92 percent / conc. HCl, MeOH / 6 h / 23 °C

5: 76 percent / pyridine / 22 h / 0 °C

6: 86 percent / pyridinium p-toluenesulfonate (PPTS) / CH₂Cl₂ / 12 h / 0 - 23 °C

7: 83 percent / K₂CO₃ / methanol / 14 h / 23 °C

8: 95 percent / NaH / dimethylformamide / 8 h / 0 °C

With pyridine; hydrogenchloride; methanol; dmap; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00176a055

Reference yield:

: 129365-60-2
(3aS,4R,5S,6S,7R,7aS)-4-Benzyloxy-7-fluoro-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

: 129365-66-8
Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / pyridine, 4-dimethylaminopyridine (DMAP) / 12 h / 23 °C

2: 92 percent / conc. HCl, MeOH / 6 h / 23 °C

3: 76 percent / pyridine / 22 h / 0 °C

4: 86 percent / pyridinium p-toluenesulfonate (PPTS) / CH₂Cl₂ / 12 h / 0 - 23 °C

5: 83 percent / K₂CO₃ / methanol / 14 h / 23 °C

6: 95 percent / NaH / dimethylformamide / 8 h / 0 °C

With pyridine; hydrogenchloride; methanol; dmap; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00176a055