N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

Base Information

Chemical Name:N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide
CAS No.:921930-96-3
Molecular Formula:C₁₉H₂₀BrNO₅
Molecular Weight:422.276
Hs Code.:

Synonyms:N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

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Chemical Property of N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

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Technology Process of N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

There total 6 articles about N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.9%

: 17275-79-5
2-bromo-3,5-dimethoxyphenylacetic acid

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 921930-96-3
N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

Guidance literature:: With 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.10.034

Reference yield:

: 921930-95-2
2-(2-bromo-3,5-dimethoxyphenyl)acetonitrile

: 921930-96-3
N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol / Heating

2: 66.9 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 °C

With sodium hydroxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.10.034

Reference yield:

: methanesulfonic acid 2-bromo-3,5-dimethoxy-benzyl ester

: 921930-96-3
N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.08 g / dimethylformamide

2: NaOH / methanol / Heating

3: 66.9 percent / N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 °C

With sodium hydroxide; 4 A molecular sieve; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.034