C₂₀H₁₉ClF₂O₅S

Base Information

• Chemical Name: C₂₀H₁₉ClF₂O₅S
• CAS No.: 1100361-34-9
• Molecular Formula: C₂₀H₁₉ClF₂O₅S
• Molecular Weight: 444.884
• Mol file: 1100361-34-9.mol

Synonyms:C₂₀H₁₉ClF₂O₅S

Chemical Property of C₂₀H₁₉ClF₂O₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉ClF₂O₅S

There total 14 articles about C₂₀H₁₉ClF₂O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((4S,4aS,10bS)-10b-((4-chlorophenyl)sulfonyl)-7,10-difluoro-1,2,4,4a,5,10b-hexahydropyrano[3,4-c]chromene-4-yl)ethanol → C20H19ClF2O5S (1100361-33-8) + C20H19ClF2O5S (1100361-34-9)

Guidance literature:

Resolution of racemate;

Reference yield:

C16H13ClF2O2S → C20H19ClF2O5S (1100361-34-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / -78 - 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / Reflux

4.1: oxone / acetone; water / 3 h / 50 °C

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.5 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: ozone; sodium tetrahydroborate; methanol / dichloromethane / -78 - 20 °C / Inert atmosphere

6.2: 1 h / Inert atmosphere

7.1: chiralcel OJ / isopropyl alcohol; hexane / Resolution of racemate

With methanol; sodium tetrahydroborate; oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; Dess-Martin periodane; ozone; methanesulfonyl chloride; triethylamine; In hexane; dichloromethane; water; isopropyl alcohol; acetone;

DOI:10.1021/ml300044f

Reference yield:

trans-4-((4-chlorophenyl)thio)-3-(1,3-dioxolan-2-yl)-5,8-difluorochroman → C20H19ClF2O5S (1100361-34-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 24 h / Reflux

2.1: oxone / acetone; water / 3 h / 50 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.5 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: ozone; sodium tetrahydroborate; methanol / dichloromethane / -78 - 20 °C / Inert atmosphere

4.2: 1 h / Inert atmosphere

5.1: chiralcel OJ / isopropyl alcohol; hexane / Resolution of racemate

With methanol; sodium tetrahydroborate; oxone; boron trifluoride diethyl etherate; ozone; methanesulfonyl chloride; triethylamine; In hexane; dichloromethane; water; isopropyl alcohol; acetone;

DOI:10.1021/ml300044f

upstream raw materials:

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester

Downstream raw materials:

C₂₇H₂₅ClF₂O₇S₂

C₂₃H₂₅ClF₂O₆S₂

C₂₂H₂₃ClF₂O₆S₂

SCH 900229