(2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

Base Information

• Chemical Name: (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
• CAS No.: 849241-80-1
• Molecular Formula: C₁₈H₁₉ClIN₅O₄
• Molecular Weight: 531.737

Synonyms:(2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

Chemical Property of (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

Chemical Property:

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Technology Process of (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

There total 3 articles about (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H31ClIN5O7 → (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol (849241-80-1)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1021/jm049408n

Reference yield:

3-iodobenzylamine hydrochloride (3718-88-5) → (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol (849241-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / ethanol / 2 h / Heating

2: NH₃ / methanol / 20 °C

With TEA; ammonia; In methanol; ethanol;

DOI:10.1021/jm049408n

Reference yield:

2,6-dichloro-9-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine (205171-10-4) → (2R,3R,4R,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol (849241-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / ethanol / 2 h / Heating

2: NH₃ / methanol / 20 °C

With TEA; ammonia; In methanol; ethanol;

DOI:10.1021/jm049408n

upstream raw materials:

3-iodobenzylamine hydrochloride

2,6-dichloro-9-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine

Downstream raw materials:

ethyl 1-deoxy-1-[N⁶-(3-iodobenzyl)-2-chloro-9H-purin-9-yl]-2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranuroate

1-deoxy-1-[N⁶-(3-iodobenzyl)-2-chloro-9H-purin-9-yl]-2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranoic acid

(2S,3R,4R,5R)-5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid methylamide

N⁶-(3-iodobenzyl)-2-chloro-9H-(2-C-methyl-2,3-O-isopropylidene-β-D-ribofuranosyl)adenine

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