2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1085538-41-5
• Molecular Formula: C₁₈H₂₄ClNO₂
• Molecular Weight: 321.847

Synonyms:2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride + chloroacetyl chloride (79-04-9) → 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline (1085538-41-5)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 4 - 20 ℃; for 1h;

DOI:10.1016/j.bmc.2015.05.053

Reference yield:

2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline (1085538-41-5) + 2-(cyclopent-1-en-1-yl)ethan-1-amine monohydrochloride → C25H36N2O2 (1085538-43-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 70 ℃; for 5h;

Reference yield:

(2R)-hydroxypropylamine (2799-16-8) + 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline (1085538-41-5) + oxalic acid (144-62-7,97993-78-7) → 1-(1-cyclohexyl-7-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-{[(2R)-2-hydroxypropyl]amino}ethanone oxalate

Guidance literature:

(2R)-hydroxypropylamine; 2-(chloroacetyl)-1-cyclohexyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 70 ℃; for 7h;

oxalic acid; In isopropyl alcohol;

DOI:10.1016/j.bmc.2015.05.053

upstream raw materials:

chloroacetyl chloride

Downstream raw materials:

C₂₅H₃₆N₂O₂

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