(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

Base Information

Chemical Name:(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester
CAS No.:90741-36-9
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

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Chemical Property of (2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

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Technology Process of (2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

There total 10 articles about (2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 90741-33-6
(2S)-1-benzyl-(E)-5-<(methoxycarbonyl)methylidene>proline tert-butyl ester

: 90741-36-9
(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; for 20h; under 2400.24 Torr; Inert atmosphere;

Reference yield: 2.0%

: 90741-33-6
(2S)-1-benzyl-(E)-5-<(methoxycarbonyl)methylidene>proline tert-butyl ester

: 90741-36-9
(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

: (2S)-trans-1-benzyl-5-<(methoxycarbonyl)methyl>-proline tert-butyl ester

Guidance literature:: With hydrogen; platinum on activated charcoal; In ethyl acetate; for 16h; under 3102.9 Torr;
DOI:10.1021/jo960759m

Reference yield:

: 90741-31-4
(S)-N-benzyl-5-thioxoproline tert-butyl ester

: 90741-36-9
(2R-cis)-5-((1,1-Dimethylethoxy)carbonyl)-1-(phenylmethyl)-2-pyrrolidineacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) Ph₃P, NMP / 1.) CH₃CN, 42 h, 2.) CH₂Cl₂, -5 deg C, 30 h.

2: 98 percent / H₂ / Pt/C / ethyl acetate / 16 h / 3102.9 Torr

With 1-methyl-pyrrolidin-2-one; hydrogen; triphenylphosphine; platinum on activated charcoal; In ethyl acetate;
DOI:10.1021/jo960759m