6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine

Base Information

• Chemical Name: 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine
• CAS No.: 144969-90-4
• Molecular Formula: C₂₀H₁₇N₃O₂S
• Molecular Weight: 363.44
• Mol file: 144969-90-4.mol

Synonyms:6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine

Chemical Property of 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine

There total 3 articles about 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

piperidinium 6-hydroxy-6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4,5,6-tetrahydropyridine-2-thiolate → 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine (144969-90-4)

Guidance literature:

With acetic acid; In ethanol; Heating;

DOI:10.1007/BF00772903

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine (144969-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / ethanol / 1 h / Ambient temperature

2: 80 percent / glacial acetic acid / ethanol / Heating

With acetic acid; In ethanol;

DOI:10.1007/BF00772903

Reference yield:

2-cyano-3-(pyrid-3'-yl)-1,4,5,6-tetrahydropyridine-2-thiolate (109628-96-8) → 6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)-1,4-dihydropyridine-2-thione betaine (144969-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / ethanol / 1 h / Ambient temperature

2: 80 percent / glacial acetic acid / ethanol / Heating

With acetic acid; In ethanol;

DOI:10.1007/BF00772903

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

2-cyano-3-(pyrid-3'-yl)-1,4,5,6-tetrahydropyridine-2-thiolate

Downstream raw materials:

2-carbamoyl-6-phenyl-5-ethoxycarbonyl-3-cyano-4-(pyrid-3'-yl)pyridine