N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide

Base Information

Chemical Name:N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide
CAS No.:91098-73-6
Molecular Formula:C₂₅H₃₄N₄O₄
Molecular Weight:454.569
Hs Code.:
DSSTox Substance ID:DTXSID801348887

Synonyms:DTXSID801348887;91098-73-6;N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide

Suppliers and Price of N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:454.25800558
Heavy Atom Count:33
Complexity:604

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N(C1=CC=C(C=C1)OC)C(C)CN2CCN(CC2)CCC3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide

There total 4 articles about N-(4-Methoxyphenyl)-N-[1-methyl-2-[4-[2-(4-nitrophenyl)ethyl]-1-piperazinyl]ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 91098-73-6
1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-nitrophenethyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / methanol; dioxane / 1.5 h / 60 °C

2: benzene / 1.5 h / 0 - 3 °C

3: 65.2 percent / K₂CO₃ / ethanol / 10 h / Heating

4: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

5: 64.6 percent / 3 h / 100 °C

With sodium tetrahydroborate; aluminium trichloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; benzene;
DOI:10.1248/cpb.32.986

Reference yield:

: 91098-70-3
2-Bromo-1-{4-[2-(4-nitro-phenyl)-ethyl]-piperazin-1-yl}-propan-1-one

: 91098-73-6
1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-nitrophenethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 65.2 percent / K₂CO₃ / ethanol / 10 h / Heating

2: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

3: 64.6 percent / 3 h / 100 °C

With sodium tetrahydroborate; aluminium trichloride; potassium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.32.986

Reference yield:

: 91098-71-4
1-<2-(p-methoxyphenylamino)propionyl>-4-(p-nitrophenethyl)piperazine

: 91098-73-6
1-<2-methyl-2-(N-propionyl-p-methoxyphenylamino)ethyl>-4-(p-nitrophenethyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 76.9 percent / AlCl₃, NaBH₄ / tetrahydrofuran / 20 h / Heating

2: 64.6 percent / 3 h / 100 °C

With sodium tetrahydroborate; aluminium trichloride; In tetrahydrofuran;
DOI:10.1248/cpb.32.986