((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

Base Information

Chemical Name:((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane
CAS No.:1359761-45-7
Molecular Formula:C₃₀H₅₆O₂Si₂
Molecular Weight:504.944
Hs Code.:

Synonyms:((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

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Technology Process of ((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

There total 8 articles about ((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1359761-25-3
triethyl (((1R,5S)-2-methyl-5-(prop-1-en-2-yl)-1-(prop-2-yn-1-yl)-3-(((triisopropylsilyl)-oxy)methyl)cyclohex-2-en-1-yl)oxy)silane

: 74-88-4
methyl iodide

: 1359761-45-7
((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

Guidance literature:: triethyl (((1R,5S)-2-methyl-5-(prop-1-en-2-yl)-1-(prop-2-yn-1-yl)-3-(((triisopropylsilyl)-oxy)methyl)cyclohex-2-en-1-yl)oxy)silane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300058t

Reference yield:

: 1359761-41-3
(1R,5S)-2-methyl-5-(prop-1-en-2-yl)-1-(prop-2-yn-1-yl)-3-(((triisopropylsilyl)oxy)methyl)cyclohex-2-enol

: 1359761-45-7
((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 72 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol300058t

Reference yield:

: trans-(5R)-1-(hydroxymethyl)-5-isopropenyl-2-methylcyclohex-2-ene-1-ol

: 1359761-45-7
((1R,5S)-1-(but-2-ynyl)-2-methyl-5-(prop-1-en-2-yl)-3-((triisopropylsilyloxy)methyl)cyclohex-2-enyloxy)triethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 54 h / 23 °C

3.1: iodine; magnesium; mercury dichloride / diethyl ether; toluene / 20 h / 20 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; iodine; magnesium; pyridinium chlorochromate; mercury dichloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol300058t