Technology Process of N-[3-(1H-imidazol-4-yl)phenyl]-6-oxo-7,8,9,10-tetrahydro-6H-pyrido[3',2':4,5]pyrrolo[1,2-a][1,4]diazepine-2-carboxamide
There total 6 articles about N-[3-(1H-imidazol-4-yl)phenyl]-6-oxo-7,8,9,10-tetrahydro-6H-pyrido[3',2':4,5]pyrrolo[1,2-a][1,4]diazepine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium diacetate; (diphenylphosphin)ferrocene / ethanol / 15 h / 110 °C / 12929 Torr / Autoclave; Inert atmosphere
2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C
2.2: 3 h / 20 °C
3.1: sodium hydroxide / ethanol / 5 h / 50 °C
3.2: pH 5
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h
4.2: 16 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; trifluoroacetic acid; sodium hydroxide;
(diphenylphosphin)ferrocene; palladium diacetate;
In
1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium fluoride / tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h
2.2: 16 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C
With
potassium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; trifluoroacetic acid;
tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
![6-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-7,8,9,10-tetrahydro-6H-pyrido[3',2':4,5]pyrrolo[1,2-a][1,4]diazepine-2-carboxamide](/Databaselist/images/loading.webp)
