(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

Base Information

Chemical Name:(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester
CAS No.:796039-57-1
Molecular Formula:C₁₇H₂₄N₂O₅
Molecular Weight:336.388
Hs Code.:

Synonyms:(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

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Chemical Property of (1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

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Technology Process of (1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

There total 6 articles about (1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 108-24-7
acetic anhydride

: 796039-44-6
(1'R,2'R)-[1-(2-carbamoyl-2-hydroxyethyl)-2-methylpropyl]carbamic acid benzyl ester

: 796039-57-1
(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ol048252i

Reference yield:

: 6216-65-5
N-benzyloxycarbonyl-L-valinol

: 796039-57-1
(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaBr; TEMPO; NaOCl / H₂O; toluene; ethyl acetate / 4 h / 0 °C

2.1: 3.9 g / CH₂Cl₂ / 14 h / 0 - 20 °C

3.1: 80 percent / rac-BINAP; t-BuONa; CuCl / polymethylhydrosiloxane / toluene / 72 h / 20 °C

4.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

4.2: 66 percent / (+/-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h / -78 °C

5.1: 77 percent / NH₃ / methanol / 14 h / -78 - 20 °C

6.1: 75 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; ammonia; sodium hexamethyldisilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium bromide; copper(l) chloride; sodium t-butanolate; polymethylhydrosiloxane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene; 2.1: Wiitig olefination;
DOI:10.1021/ol048252i

Reference yield:

: 138754-84-4,95500-73-5
N-benzyloxycarbonyl-L-valinal

: 796039-57-1
(1R,3R)-acetic acid 3-benzyloxycarbonylamino-1-carbamoyl-4-methylpentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.9 g / CH₂Cl₂ / 14 h / 0 - 20 °C

2.1: 80 percent / rac-BINAP; t-BuONa; CuCl / polymethylhydrosiloxane / toluene / 72 h / 20 °C

3.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: 66 percent / (+/-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine / tetrahydrofuran / 1 h / -78 °C

4.1: 77 percent / NH₃ / methanol / 14 h / -78 - 20 °C

5.1: 75 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; ammonia; sodium hexamethyldisilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(l) chloride; sodium t-butanolate; polymethylhydrosiloxane; In tetrahydrofuran; methanol; dichloromethane; toluene; 1.1: Wiitig olefination;
DOI:10.1021/ol048252i