Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate

Base Information

Chemical Name:Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate
CAS No.:153938-42-2
Molecular Formula:C₁₉H₁₇NO₅
Molecular Weight:339.348
Hs Code.:
DSSTox Substance ID:DTXSID301147129

Synonyms:DTXSID301147129;Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate;153938-42-2

Suppliers and Price of Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:339.11067264
Heavy Atom Count:25
Complexity:496

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)CC1=CC(=CC=C1)OCCN2C(=O)C3=CC=CC=C3C2=O

Technology Process of Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate

There total 1 articles about Methyl 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 153938-42-2
methyl 3-(2-phthalimidoethoxy)phenyl acetate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/0223-5234(93)90093-T

Reference yield:

: 153938-42-2
methyl 3-(2-phthalimidoethoxy)phenyl acetate

: 916198-24-8
[3-(2-Amino-ethoxy)-phenyl]-acetic acid methyl ester

Guidance literature:: With hydrazine hydrate; In methanol; for 8h; Heating;
DOI:10.1016/0223-5234(93)90093-T

Reference yield:

: 153938-42-2
methyl 3-(2-phthalimidoethoxy)phenyl acetate

: [3-(2-Benzenesulfonylamino-ethoxy)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. N₂H₄ / methanol / 8 h / Heating

2: NEt₃ / CH₂Cl₂ / 18 h / Ambient temperature

3: aq. NaOH / ethanol / 3 h / Heating

With sodium hydroxide; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/0223-5234(93)90093-T