6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine

Base Information

• Chemical Name: 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine
• CAS No.: 126684-50-2
• Molecular Formula: C₂₀H₁₉N₅O₄S
• Molecular Weight: 425.468

Synonyms:6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine

Chemical Property of 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine

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Technology Process of 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine

There total 2 articles about 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-amino-6,7-bis(4-methoxyphenyl)-1H-pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide + methyl iodide (74-88-4) → 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ6-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine (126684-50-2)

Guidance literature:

With triethylamine; In acetone; for 72h; Heating;

DOI:10.1021/jm981104b

Reference yield:

1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → 6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ6-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine (126684-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / aq. HCl / methanol / 24 h / Heating

2: 73 percent / Et₃N / acetone / 72 h / Heating

With hydrogenchloride; triethylamine; In methanol; acetone; 1: cyclocondensation / 2: Methylation;

DOI:10.1021/jm981104b

Reference yield: 70.0%

6,7-Bis-(4-methoxy-phenyl)-1-methyl-2,2-dioxo-1,2-dihydro-2λ6-pyrazino[2,3-c][1,2,6]thiadiazin-4-ylamine (126684-50-2) → 6,7-bis(4-methoxyphenyl)-1-methyl-1H-pyrazino[2,3-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxide (556019-78-4)

Guidance literature:

With potassium carbonate; In methanol; water; for 2h; Heating;

DOI:10.1002/hlca.200390003

upstream raw materials:

methyl iodide

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

Downstream raw materials:

6,7-bis(4-methoxyphenyl)-1-methyl-1H-pyrazino[2,3-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxide

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