Technology Process of Acetic acid (1S,2R)-1-bromomethyl-2-methyl-pentyl ester
There total 2 articles about Acetic acid (1S,2R)-1-bromomethyl-2-methyl-pentyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 50 percent / acetic acid / 0.08 h / Heating
2: 12.2 g / NaOH, Aspergillus acylase, CoCl2 / H2O / 120 h / 37 °C / pH=6.5
3: 63 percent / 2N HCl / 2 h / Heating
4: 82 percent / NaNO2, 1.5N H2SO4 / H2O / 1.) 0-5 deg C, 1 h; 2.) 0-30 deg C, 2 h
5: 56 percent / LAH / diethyl ether / 1.) 0-5 deg C, 1 h; 2.) RT, 1 h
6: 30percent HBr / H2O / 1.) 0-5 deg C, 10 min; 2.) RT, 1 h
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; Aspergillus acylase; sulfuric acid; hydrogen bromide; sodium nitrite;
In
diethyl ether; water; acetic acid;
DOI:10.1016/0040-4020(80)80113-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / acetic acid / 0.08 h / Heating
2: 55 percent / NaOH, Aspergillus acylase, CoCl2 / H2O / 96 h / 37 °C / pH = 6.7 to 6.8
3: 66 percent / NaNO2, 1.5N H2SO4 / H2O / 1.) 0-5 deg C, 1 h; 2.) 0-30 deg C, 2h
4: 75 percent / LAH / diethyl ether / 1.) 0-5 deg C, 1 h; 2.) RT, 1 h
5: 30percent HBr / H2O / 1.) 0-5 deg C, 10 min; 2.) RT, 1 h
With
sodium hydroxide; lithium aluminium tetrahydride; Aspergillus acylase; sulfuric acid; hydrogen bromide; sodium nitrite;
In
diethyl ether; water; acetic acid;
DOI:10.1016/0040-4020(80)80113-X
