5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

Base Information

Chemical Name:5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride
CAS No.:1021873-73-3
Molecular Formula:C₁₄H₁₄ClN₃O₃S*ClH
Molecular Weight:376.263
Hs Code.:

Synonyms:5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

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Chemical Property of 5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

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Technology Process of 5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

There total 2 articles about 5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 70097-69-7
2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide

: 771573-22-9
1-[3-(methylsulfonyl)phenyl]methanamine

: 1021873-73-3
5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

Guidance literature:: 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide; 1-[3-(methylsulfonyl)phenyl]methanamine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h; Cooling with ice;

In water; dimethyl sulfoxide; at 80 ℃; for 1h;

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01528

Reference yield:

: 70097-69-7
2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide

: 855267-50-4
1-(3-methanesulfonylphenyl)methanamine hydrochloride

: 1021873-73-3
5-chloro-2-imino-1-[3-(methylsulfonyl)benzyl]-1,2-dihydropyridine-3-carboxamide monohydrochloride

Guidance literature:: 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide; 1-(3-methanesulfonylphenyl)methanamine hydrochloride; With triethylamine; In methanol; ethanol; at 20 ℃; for 24h;

In dimethyl sulfoxide; at 80 ℃; for 4h;

With hydrogenchloride; In methanol;