allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate

Base Information

• Chemical Name: allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate
• CAS No.: 860617-82-9
• Molecular Formula: C₂₅H₂₇NO₆
• Molecular Weight: 437.492
• Mol file: 860617-82-9.mol

Synonyms:allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate

Chemical Property of allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate

There total 1 articles about allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl (2S,4R)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate (860617-74-9) + bromoacetic acid tert-butyl ester (5292-43-3) → allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate (860617-82-9)

Guidance literature:

allyl (2S,4R)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate; With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 0.25h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -70 - 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.04.064

Reference yield: 80.0%

allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate (860617-82-9) + sodium methylate (124-41-4) → 4-tert-butyl-1-methyl N-[(allyloxy)carbonyl]-2-phenyl-D-aspartate (860617-80-7)

Guidance literature:

In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.04.064

Reference yield:

allyl (2S,4S)-4-(2-tert-butoxy-2-oxoethyl)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate (860617-82-9) → 4-tert-butyl-1-methyl-2-phenyl-D-aspartate

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / methanol / 4 h / 20 °C

2: 85 percent Chromat_. / iodine; water / acetonitrile / 48 h / 20 °C

With water; iodine; In methanol; acetonitrile;

DOI:10.1016/j.tetlet.2005.04.064

upstream raw materials:

allyl (2S,4R)-5-oxo-2,4-diphenyl-1,3-oxazolidine-3-carboxylate

bromoacetic acid tert-butyl ester

Downstream raw materials:

4-tert-butyl-1-methyl N-[(allyloxy)carbonyl]-2-phenyl-D-aspartate