5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Base Information

Chemical Name:5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide
CAS No.:1269826-44-9
Molecular Formula:C₂₀H₁₉Cl₂F₃N₂O₃
Molecular Weight:463.284
Hs Code.:

Synonyms:5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Suppliers and Price of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

There total 11 articles about 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5-(3,4-dichlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinoyl chloride

: 13374-31-7
(1R,2R)-trans-2-aminocyclohexanol hydrochloride

: 1269826-44-9
5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: (1R,2R)-trans-2-aminocyclohexanol hydrochloride; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

5-(3,4-dichlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinoyl chloride; In tetrahydrofuran; water; at 38 ℃; for 0.75h;

Reference yield:

: 1269826-46-1
5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

: 151169-75-4
3,4-dichlophenylboronic acid

: 1269826-44-9
5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide; toluene; at 90 ℃; for 2h;

Reference yield:

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

: 1269826-44-9
5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 70 °C

2.1: trichlorophosphate / toluene / 21 h / 80 °C

2.2: 3 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 18 h / 70 °C

3.2: 2 h / 60 °C

3.3: 0.17 h / 20 °C

4.1: lithium hydroxide / dimethyl sulfoxide / 4 h / 80 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

6.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

6.2: 0.75 h / 38 °C

With N-iodo-succinimide; oxalyl dichloride; sodium carbonate; sodium hydroxide; lithium hydroxide; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;