diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate

Base Information

• Chemical Name: diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate
• CAS No.: 249571-89-9
• Molecular Formula: C₂₀H₂₆NO₄PS
• Molecular Weight: 407.471

Synonyms:diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate

Chemical Property of diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate

Chemical Property:

Purity/Quality:

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Technology Process of diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate

There total 3 articles about diethyl (S_S,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

diethyl (SS,1R,2R)-1-chloro-1-methyl-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate (249571-86-6) → diethyl (SS,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate (249571-89-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 0.333333h;

DOI:10.1021/ol990855k

Reference yield:

diethyl 1-chloroethylphosphonate (10419-78-0) → diethyl (SS,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate (249571-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / LiN(SiMe₃)2 / tetrahydrofuran / 0.33 h / -78 °C

2: 69 percent / NaH / tetrahydrofuran / 0.33 h

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1: Darzens reaction;

DOI:10.1021/ol990855k

Reference yield:

(S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → diethyl (SS,2R,3R)-2-methyl-3-phenyl-1-(p-toluenesulfinyl)-aziridine-2-phosphonate (249571-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / LiN(SiMe₃)2 / tetrahydrofuran / 0.33 h / -78 °C

2: 69 percent / NaH / tetrahydrofuran / 0.33 h

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1: Darzens reaction;

DOI:10.1021/ol990855k

upstream raw materials:

diethyl (S_S,1R,2R)-1-chloro-1-methyl-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate

diethyl 1-chloroethylphosphonate

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

Downstream raw materials:

diethyl (2R,3R)-2-methyl-3-phenyl-aziridine-2-phosphonate

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