tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Name:tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911418-58-1
Molecular Formula:C₃₉H₄₆N₈O₆
Molecular Weight:722.844
Hs Code.:

Synonyms:tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 123-75-1
pyrrolidine

: 911418-57-0
tert-butyl 5-(6-(2-chloroethoxy)-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 911418-58-1
tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: In tetrahydrofuran; N,N-dimethyl-formamide; at 85 ℃; for 2h;

Reference yield:

: 911418-46-7
7-methoxy-2-(3-nitrophenyl)-4-oxo-3,4-dihydroquinazolin-6-yl acetate

: 911418-58-1
tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride; N,N-dimethyl-formamide / 2.5 h / Heating / reflux

2: isopropyl alcohol / 5 h / Heating / reflux

3: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

4: sodium hydrogencarbonate / tetrahydrofuran; water; ethyl acetate / 5 h / 20 °C

5: sodium hydrogencarbonate / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C

6: methanol; ammonia; water / 24 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 3 h / 85 °C

8: tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 85 °C

With methanol; thionyl chloride; ammonia; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide; palladium over charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 911418-47-8
4-chloro-7-methoxy-2-(3-nitrophenyl)quinazolin-6-yl acetate

: 911418-58-1
tert-butyl 5-(7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: isopropyl alcohol / 5 h / Heating / reflux

2: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water; ethyl acetate / 5 h / 20 °C

4: sodium hydrogencarbonate / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C

5: methanol; ammonia; water / 24 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 3 h / 85 °C

7: tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 85 °C

With methanol; ammonia; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium over charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;