(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

Base Information

Chemical Name:(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane
CAS No.:201012-05-7
Molecular Formula:C₄₀H₇₄O₁₀Si₂
Molecular Weight:771.193
Hs Code.:

(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

Synonyms:(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

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Chemical Property of (2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

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Technology Process of (2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

There total 18 articles about (2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 107-30-2
chloromethyl methyl ether

: 201012-04-6
(2S,4R,5S)-1-[(2R,4R,5R,6S)-6-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxan-4-yl]-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexan-2-ol

: 201012-05-7
(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 17h; Ambient temperature;

Reference yield:

: 101470-81-9
(2R,3S)-1-Benzyloxymethyloxy-2-methylbutan-3-ol

: 201012-05-7
(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / i-Pr₂NEt / CH₂Cl₂ / 0.67 h / Ambient temperature

2: 84.9 percent / H₂ / 50percent Raney Ni / ethanol / 120 h / Ambient temperature

3: 78.1 percent / Ph₃P, imidazole, I₂ / benzene / 0.33 h / Ambient temperature

4: 38 percent / t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 10 min; r.t., 1 h, 2.) r.t., 11 h

5: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 17 h / Ambient temperature

With 1H-imidazole; hydrogen; iodine; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel; In diethyl ether; ethanol; dichloromethane; pentane; benzene;

Reference yield:

: 201011-94-1
[2-((1S,2R)-3-Benzyloxymethoxy-1,2-dimethyl-propoxymethoxy)-ethyl]-trimethyl-silane

: 201012-05-7
(2R,4S,5R,6R)-4-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-ethyl]-6-[(2S,4R,5S)-2-methoxymethoxy-4-methyl-5-(2-trimethylsilanyl-ethoxymethoxy)-hexyl]-2-(4-methoxy-phenyl)-5-triethylsilanyloxy-[1,3]dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 84.9 percent / H₂ / 50percent Raney Ni / ethanol / 120 h / Ambient temperature

2: 78.1 percent / Ph₃P, imidazole, I₂ / benzene / 0.33 h / Ambient temperature

3: 38 percent / t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 10 min; r.t., 1 h, 2.) r.t., 11 h

4: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 17 h / Ambient temperature

With 1H-imidazole; hydrogen; iodine; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel; In diethyl ether; ethanol; dichloromethane; pentane; benzene;