2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide
CAS No.:1333223-40-7
Molecular Formula:C₂₄H₂₁FN₂O₅S
Molecular Weight:468.506
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

There total 7 articles about 2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1333224-88-6
2-(4-fluorophenyl)-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxylic acid

: 593-56-6
N-methoxylamine hydrochloride

: 1333223-40-7
2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: 2-(4-fluorophenyl)-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

N-methoxylamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333223-40-7
2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

With pyridine; potassium phosphate tribasic trihydrate; water; iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333223-40-7
2-(4-fluorophenyl)-N-methoxy-6-[methyl(methylsulfonyl)amino]-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

With pyridine; potassium phosphate tribasic trihydrate; water; iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;