2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

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Chemical Name:2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid
CAS No.:1293283-00-7
Molecular Formula:C₂₁H₁₇F₄N₇O₃
Molecular Weight:491.405
Hs Code.:

Synonyms:2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

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Chemical Property of 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

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Technology Process of 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

There total 9 articles about 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1293286-18-6
methyl 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl )hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl)pyrimidine-5-carboxylate

: 1293283-00-7
2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

Guidance literature:: With hydrogenchloride; water;

Reference yield:

: 86732-22-1
2-benzyloctahydropyrrolo[3,4-c]pyrrole

: 1293283-00-7
2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 24 h / 23 °C

2: hydrogen / palladium 10% on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr

3: sodium carbonate / toluene; water / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: caesium carbonate / ISOPROPYLAMIDE / 72 h / 100 °C

6: hydrogenchloride; water

With hydrogenchloride; water; hydrogen; sodium carbonate; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE; water; acetic acid; toluene;

Reference yield:

: 186202-73-3
tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate

: 1293283-00-7
2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr

2: sodium carbonate / toluene; water / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: caesium carbonate / ISOPROPYLAMIDE / 72 h / 100 °C

5: hydrogenchloride; water

With hydrogenchloride; water; hydrogen; sodium carbonate; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE; water; acetic acid; toluene;