methyl 4-((2-bromophenyl)ethynyl)benzoate

Base Information

• Chemical Name: methyl 4-((2-bromophenyl)ethynyl)benzoate
• CAS No.: 1192159-83-3
• Molecular Formula: C₁₆H₁₁BrO₂
• Molecular Weight: 315.166
• Mol file: 1192159-83-3.mol

Synonyms:methyl 4-((2-bromophenyl)ethynyl)benzoate

Chemical Property of methyl 4-((2-bromophenyl)ethynyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 4-((2-bromophenyl)ethynyl)benzoate

There total 2 articles about methyl 4-((2-bromophenyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-iodobenzoate (619-44-3) + 2-bromo-1-ethynylbenzene (766-46-1) → methyl 4-((2-bromophenyl)ethynyl)benzoate (1192159-83-3)

Guidance literature:

methyl 4-iodobenzoate; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 0.166667h; Inert atmosphere;

2-bromo-1-ethynylbenzene; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01543

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) + 4-ethynylbenzoic acid methyl ester (3034-86-4) → methyl 4-((2-bromophenyl)ethynyl)benzoate (1192159-83-3)

Guidance literature:

1-Bromo-2-iodobenzene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 0.25h; Inert atmosphere;

4-ethynylbenzoic acid methyl ester; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03533

Reference yield: 80.0%

methyl 4-((2-bromophenyl)ethynyl)benzoate (1192159-83-3) → 4-(indol-2-yl)benzoic acid methyl ester (485321-10-6)

Guidance literature:

With palladium diacetate; S-tert-butylsulfinimide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.08.075

upstream raw materials:

1-Bromo-2-iodobenzene

4-ethynylbenzoic acid methyl ester

methyl 4-iodobenzoate

2-bromo-1-ethynylbenzene

Downstream raw materials:

4-(indol-2-yl)benzoic acid methyl ester