5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

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Chemical Name:5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride
CAS No.:1261138-08-2
Molecular Formula:C₁₈H₁₈ClN₅O₃S*ClH
Molecular Weight:456.353
Hs Code.:

Synonyms:5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

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Chemical Property of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

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Technology Process of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

There total 9 articles about 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1261138-19-5
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4-t-butoxycarbonyl-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene carboxamide

: 1261138-08-2
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 1h; Product distribution / selectivity; Reflux;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1261138-08-2
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetonitrile / 19 h / 80 °C

1.2: 1 h / 0 °C

2.1: phosphorus tribromide / 1,2-dimethoxyethane / 4.5 h / 0 - 60 °C

2.2: 0.5 h / pH 4

3.1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

4.1: dmap / tetrahydrofuran / 1.5 h / Reflux

5.1: zinc; ammonium chloride / methanol / 13 h / 65 °C

6.1: 2-methyl-propan-1-ol / 18 h / Reflux

7.1: dmap / tetrahydrofuran / 18 h / Reflux

8.1: hydrogenchloride / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; sodium acetate; phosphorus tribromide; potassium carbonate; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methyl-propan-1-ol; acetonitrile;

Reference yield:

: 43214-49-9
2-[N-(4-nitro-phenyl)-hydrazino]-ethanol

: 1261138-08-2
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / 1,2-dimethoxyethane / 4.5 h / 0 - 60 °C

1.2: 0.5 h / pH 4

2.1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

3.1: dmap / tetrahydrofuran / 1.5 h / Reflux

4.1: zinc; ammonium chloride / methanol / 13 h / 65 °C

5.1: 2-methyl-propan-1-ol / 18 h / Reflux

6.1: dmap / tetrahydrofuran / 18 h / Reflux

7.1: hydrogenchloride / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; sodium acetate; phosphorus tribromide; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methyl-propan-1-ol;