N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

Base Information

Chemical Name:N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine
CAS No.:1400691-81-7
Molecular Formula:C₂₀H₂₀F₄N₆O
Molecular Weight:436.412
Hs Code.:

Synonyms:N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

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Chemical Property of N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

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Technology Process of N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

There total 6 articles about N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 68322-84-9
2-bromo-1-fluoro-4-(trifluoromethyl)benzene

: 1400692-12-7
C₁₃H₁₈N₆O

: 1400692-11-6
C₁₃H₁₈N₆O

: 1400691-82-8
C₂₀H₂₀F₄N₆O

: 1400691-81-7
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

Guidance literature:: With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-butyl alcohol; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 7379-35-3
4-chlorpyridine hydrochloride

: 1400691-81-7
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / dimethyl sulfoxide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 25 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

4.1: isopropyl alcohol / 6 h / Reflux

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 900511-91-3
4-[(1-benzylpiperidin-4-yl)oxy]-pyridine

: 1400691-81-7
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-[4-(4-pyridinyloxy)-1-piperidinyl]-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 25 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

3: isopropyl alcohol / 6 h / Reflux

4: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 16 h / 100 °C / Inert atmosphere

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; dichloromethane; isopropyl alcohol; tert-butyl alcohol;