N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine
• CAS No.: 1214923-70-2
• Molecular Formula: C₂₂H₂₇FN₄O₂
• Molecular Weight: 398.48

Synonyms:N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine

Chemical Property of N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine

There total 5 articles about N₄-(3-allyloxy-cyclohexyl)-N₂-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-aminocyclohexanol (6850-39-1) → N4-(3-allyloxy-cyclohexyl)-N2-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine (1214923-70-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / water / 0.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C

3: hydrogenchloride; water / acetone / 0.5 h / Reflux

4: sodium hydrogencarbonate / ethanol; water / 40 h / 70 °C

5: trifluoroacetic acid / isopropyl alcohol / 100 °C / sealed vessel

With hydrogenchloride; water; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil;

Reference yield:

(3-Allyloxy-cyclohexyl)-(2-chloro-5-fluoro-pyrimidin-4-yl)-amine (1214923-69-9) + 3-allyloxy-phenylamine (74900-81-5) → N4-(3-allyloxy-cyclohexyl)-N2-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine (1214923-70-2)

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃; sealed vessel;

Reference yield:

3-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexanol (1214923-66-6) → N4-(3-allyloxy-cyclohexyl)-N2-(3-allyloxy-phenyl)-5-fluoro-pyrimidine-2,4-diamine (1214923-70-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C

2: hydrogenchloride; water / acetone / 0.5 h / Reflux

3: sodium hydrogencarbonate / ethanol; water / 40 h / 70 °C

4: trifluoroacetic acid / isopropyl alcohol / 100 °C / sealed vessel

With hydrogenchloride; water; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil;

upstream raw materials:

3-aminocyclohexanol

(3-Allyloxy-cyclohexyl)-(2-chloro-5-fluoro-pyrimidin-4-yl)-amine

3-allyloxy-phenylamine

3-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexanol

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