(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

Base Information

Chemical Name:(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime
CAS No.:1615228-37-9
Molecular Formula:C₂₈H₂₇N₃O₂
Molecular Weight:437.541
Hs Code.:

Synonyms:(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

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Chemical Property of (Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

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Technology Process of (Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

There total 3 articles about (Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1312032-82-8
C₁₃H₁₀ClNO

: 4-benzyl-1-(isocyanoacetyl)piperidine

: 1615228-37-9
(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo5005444

Reference yield:

: 40143-27-9
biphenyl-4-carbaldehyde oxime

: 1615228-37-9
(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; In dichloromethane;
DOI:10.1021/jo5005444

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 1615228-37-9
(Z)-[1,1′-biphenyl]-4-yl(5-(4-benzylpiperidin-1-yl)oxazol-2-yl)methanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1: neat (no solvent)

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylamine; In dichloromethane;
DOI:10.1021/jo5005444