(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

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Chemical Name:(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride
CAS No.:127559-22-2
Molecular Formula:C₃₁H₃₄N₄O₁₀*ClH
Molecular Weight:659.093
Hs Code.:

(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

Synonyms:(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

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Chemical Property of (S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

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Technology Process of (S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

There total 17 articles about (S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127559-21-1
(S)-O-<5-<2-<<(Phenylmethoxy)carbonyl>amino>-2-carboxyethyl>-2-hydroxyphenyl>-N--L-asparaginyl>-L-tyrosine methyl ester

: 127559-22-2
(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 0.5h;
DOI:10.1016/S0040-4039(01)93447-1

Reference yield:

: 120385-11-7
N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

: 127559-22-2
(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / LiOH, H₂O / tetrahydrofuran; methanol

2: 86 percent / EDCI, HOBt / CH₂Cl₂ / 12 h / 25 °C

3: 70 percent / CBr₄, Ph₃P / diethyl ether / 12 h / 25 °C

4: NaH / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) -78 deg C, 12 h

5: 0.5 N aq. HCl / tetrahydrofuran / 14 h / 25 °C

6: 88 percent / EDCI, HOBt / dimethylformamide / 12 h / 25 °C

7: H₂ / Pd-C / tetrahydrofuran / 3 h / 25 °C

8: NaHCO₃ / tetrahydrofuran / 25 °C

9: 90 percent / n-Bu₄NF / dimethylformamide / 4 h / 25 °C

10: 3.0 M HCl / ethyl acetate / 0.5 h / 25 °C

With hydrogenchloride; lithium hydroxide; carbon tetrabromide; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93447-1

Reference yield:

: 127559-15-3
N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine

: 127559-22-2
(S)-3-(3-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-hydroxy-phenyl)-2-benzyloxycarbonylamino-propionic acid; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / EDCI, HOBt / CH₂Cl₂ / 12 h / 25 °C

2: 70 percent / CBr₄, Ph₃P / diethyl ether / 12 h / 25 °C

3: NaH / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) -78 deg C, 12 h

4: 0.5 N aq. HCl / tetrahydrofuran / 14 h / 25 °C

5: 88 percent / EDCI, HOBt / dimethylformamide / 12 h / 25 °C

6: H₂ / Pd-C / tetrahydrofuran / 3 h / 25 °C

7: NaHCO₃ / tetrahydrofuran / 25 °C

8: 90 percent / n-Bu₄NF / dimethylformamide / 4 h / 25 °C

9: 3.0 M HCl / ethyl acetate / 0.5 h / 25 °C

With hydrogenchloride; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93447-1