(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

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Chemical Name:(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide
CAS No.:952423-73-3
Molecular Formula:C₂₁H₃₀F₃N₃O₂S
Molecular Weight:445.549
Hs Code.:

Synonyms:(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

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Chemical Property of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

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Technology Process of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

There total 8 articles about (S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952506-27-3
(S)-2-methyl-propane-2-sulfinic acid [(R)-1-{3-exo-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetyl]-8-aza-bicyclo[3.2.1]oct-3-yl}-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

: 952423-73-3
(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

Guidance literature:: With hydrazine; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 532-24-1
tropinone

: 952423-73-3
(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / toluene / 16 h / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 - 0 °C

2.2: 0.5 h / -40 - 0 °C

3.1: hydrogenchloride; water / acetone / 24 h / 50 °C

4.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

4.2: 16 h / 50 °C

5.1: magnesium / diethyl ether / 0.5 h / 20 °C

5.2: 4 h / 0 - 20 °C

5.3: 0 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 1 h / 20 °C

7.2: 16 h / 20 °C

8.1: hydrazine / ethanol / 16 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; magnesium sulfate; potassium carbonate; magnesium; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; 1,2-dichloro-ethane; acetone; toluene; acetonitrile;

Reference yield:

: 952423-57-3
benzyl 3-formyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 952423-73-3
(S)-2-methyl-propane-2-sulfinic acid [(R)-1-[3-exo-8-(2-amino-acetyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

1.2: 16 h / 50 °C

2.1: magnesium / diethyl ether / 0.5 h / 20 °C

2.2: 4 h / 0 - 20 °C

2.3: 0 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 1 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrazine / ethanol / 16 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; pyridinium p-toluenesulfonate; magnesium sulfate; magnesium; hydrazine; palladium 10% on activated carbon; In diethyl ether; ethanol; 1,2-dichloro-ethane; acetonitrile;