4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

Base Information

Chemical Name:4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline
CAS No.:1436689-07-4
Molecular Formula:C₂₃H₁₂Cl₂F₃N₃
Molecular Weight:458.27
Hs Code.:

Synonyms:4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

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Chemical Property of 4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

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Technology Process of 4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

There total 6 articles about 4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 60611-22-5
2-chloro-6-(trifluoromethyl)benzaldehyde

: 1436688-89-9
2-chloro-7-phenylquinoline-3,4-diamine

: 1436689-07-4
4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

Guidance literature:: With sodium pyrosulfate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 6h;
DOI:10.1016/j.bmc.2013.03.069

Reference yield:

: 1436688-80-0
3-nitro-7-phenylquinoline-2,4-diol

: 1436689-07-4
4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 2 h / Reflux

2: ammonia / acetonitrile; water / 6.5 h / 20 - 50 °C

3: platinum on carbon; hydrogen / ethyl acetate; methanol / 6 h / 20 °C

4: sodium pyrosulfate / 1-methyl-pyrrolidin-2-one / 6 h / 140 °C

With sodium pyrosulfate; platinum on carbon; ammonia; hydrogen; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2013.03.069

Reference yield:

: 1436688-77-5
7-bromo-3-nitroquinoline-2,4-diol

: 1436689-07-4
4-chloro-2-(2-chloro-6-(trifluoromethyl)phenyl)-7-phenylimidazo[4,5-c]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide; water / 5 h / 80 °C

2: trichlorophosphate / 2 h / Reflux

3: ammonia / acetonitrile; water / 6.5 h / 20 - 50 °C

4: platinum on carbon; hydrogen / ethyl acetate; methanol / 6 h / 20 °C

5: sodium pyrosulfate / 1-methyl-pyrrolidin-2-one / 6 h / 140 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium pyrosulfate; platinum on carbon; ammonia; hydrogen; sodium carbonate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.03.069