2-CHLORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Base Information

• Chemical Name: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS No.: 60611-22-5
• Molecular Formula: C8H4ClF3O
• Molecular Weight: 208.567
• Hs Code.: 2913000090
• Mol file: 60611-22-5.mol

Synonyms:2-trifluoromethyl-6-chloro-benzaldehyde;3-Chloro-2-formylbenzotrifluoride;2-chloro-6-trifluoromethylbenzaldehyde;Benzaldehyde,2-chloro-6-(trifluoromethyl);JRD-1816;2-Chlor-6-trifluormethylbenzaldehyd;

Chemical Property of 2-CHLORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.165mmHg at 25°C
• Boiling Point: 213.3oC at 760 mmHg
• Flash Point: 82.8oC
• PSA: 17.07000
• Density: 1.423g/cm3
• LogP: 3.17130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-6-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE

There total 5 articles about 2-CHLORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloro-6-(trifluoromethyl)phenyl)methanol (886500-21-6) → 2-chloro-6-(trifluoromethyl)benzaldehyde (60611-22-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

2-chloro-6-(trifluoromethyl)benzoic acid (2376-00-3) → 2-chloro-6-(trifluoromethyl)benzaldehyde (60611-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosgene / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

With phosgene; lithium borohydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

methyl 2-chloro-6-(trifluoromethyl)benzoate (1214386-37-4) → 2-chloro-6-(trifluoromethyl)benzaldehyde (60611-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 20 °C

2: Dess-Martin periodane / dichloromethane / 20 °C

With lithium borohydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(2-chloro-6-(trifluoromethyl)phenyl)methanol

2-chloro-6-(trifluoromethyl)benzoic acid

methyl 2-chloro-6-(trifluoromethyl)benzoate

2-chloro-6-(trifluoromethyl)benzoyl chloride

Downstream raw materials:

1-(2-chloro-6-(trifluoromethyl)phenyl)ethanol

Refernces

• 1、 -. "N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF". Paragraph 0235. . Retrieved 2015/08/04.
• 2、 -. "N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF". Page/Page column 41-42. . Retrieved 2014/03/22.