[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

Base Information

Chemical Name:[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine
CAS No.:873668-68-9
Molecular Formula:C₂₅H₂₈N₂
Molecular Weight:356.511
Hs Code.:

Synonyms:[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

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Technology Process of [2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

There total 3 articles about [2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 873668-25-8
[2R,2(1S),3S,4S]-2-(amino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

: 100-52-7
benzaldehyde

: 873668-68-9
[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

Guidance literature:: [2R,2(1S),3S,4S]-2-(amino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine; benzaldehyde; In dichloromethane; at 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;
DOI:10.1021/ol052388e

Reference yield:

: 591-51-5
phenyllithium

: 873668-68-9
[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 78 percent / NaBH₄ / toluene; methanol / 2 h / 0 °C

2.1: MhSO₄ / CH₂Cl₂ / 1 h / 20 °C

2.2: 92 percent / NaBH₄ / methanol / 2 h / 0 °C

With MhSO₄; In dichloromethane; toluene;
DOI:10.1021/ol052388e

Reference yield:

: 452096-24-1
(2R,3S,4S)-1,4-dimethyl-3-phenyl-azetidine-2-carbonitrile

: 873668-68-9
[2R,2(1S),3S,4S]-2-(benzylamino-phenyl-methyl)-1,4-dimethyl-3-phenylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 78 percent / NaBH₄ / toluene; methanol / 2 h / 0 °C

2.1: MhSO₄ / CH₂Cl₂ / 1 h / 20 °C

2.2: 92 percent / NaBH₄ / methanol / 2 h / 0 °C

With MhSO₄; In dichloromethane; toluene;
DOI:10.1021/ol052388e